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Ovarian Cancer. Treatment of Ovarian Cancer in Young Women. Clinical Obstetrics and Gynecology55 1 , March Add Item s to:. An Existing Folder. In the subspecialty of Gynecologic Oncology, this principle has been best exemplified by the introduction of minimally invasive surgery into the management of clinical stage I endometrial cancer, FIGO stage I cervical cancer including lesions amenable to fertility-preserving radical trachelectomy , and select adnexal masses.
Some practicing Gynecologic Oncologists had little or no laparoscopic training during fellowship, and many had no robotics training. Minimally invasive workshops held by the American Association of Gynecologic Laparoscopists and by the Society of Gynecologic Oncology in collaboration with industry partners eg. While the principles of cytoreductive surgery are taught in Gynecologic Oncology fellowship training programs throughout the world, the demonstration of technique and how to safely push the envelope to accomplish optimal debulking status or even an R 0 resection appears to vary to some degree.
Although postoperative rates of adverse effects and mortality tended to be higher after primary debulking than after interval cytoreduction, this study raised a number of controversies, particularly regarding the quality of debulking surgery. While complete resection of all macroscopic disease at primary or interval surgery was the strongest independent variable in predicting OS, only These results for optimal cytoreduction rates are much lower than what is reported by many U.
For these reasons it was not surprising that beginning with the First Annual Cytoreductive Surgery Workshop in that attendees were registering from around the world, with each succeeding Workshop receiving even more participation from our global partners. The high numbers of U. Enthusiasm for these types of activities has led directly to our first Cytoreductive Surgery Workshop designed specifically for fellows-in-training. All 24 spots for this Fellows Cytoreductive Surgery Workshop were filled within two hours of its announcement.
Tewari presents his thesis, The Road to Baltimore , during didactics; d Participants attendees, faculty, and UCI fellows seen outside of the cadaver dissection laboratory. Adis; Carboplatin plus paclitaxel once a week versus every 3 weeks in patients with advanced ovarian cancer MITO-7 : a randomized, multicenter, open-label, phase 3 trial. Lancet Oncol. Intraperitoneal cisplatin and paclitaxel in ovarian cancer. N Engl J Med. Long-term survival advantage and prognostic factors associated with intraperitoneal chemotherapy treatment in advanced ovarian cancer: A Gynecologic Oncology Group study.
J Clin Oncol. Weekly vs everyweek paclitaxel and carboplatin for ovarian cancer. Gynecol Oncol. Incorporation of anti-angiogenesis therapy in the management of advanced ovarian carcinoma — Mechanistics, review of phase III randomized clinical trials, and regulatory implications. Ovarian cancer clinical trial endpoints: Society of Gynecologic Oncology white paper. Molecular subgroup of high-grade serous ovarian cancer HGSOC as a predictor of outcome following bevacizumab.
Olaparib maintenance therapy in platinum-sensitive relapsed ovarian cancer.
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PARP inhibition and synthetic lethality in ovarian cancer. Expert Rev Clin Pharmacol. Development of olaparib for BRCA-deficient recurrent epithelial ovarian cancer. Clin Cancer Res. Results of ARIEL2: A Phase 2 trial to prospectively identify ovarian cancer patietns likely to respond to rucaparib using tumor genetic analysis. New targeted agents in gynecologic cancers: Synthetic lethality, homologous recombination deficiency, and PARP inhibitors.
Curr Treat Options Oncol. Recent patents for homologous recombination deficiency assays among women with ovarian cancer. Recent Pat Biotechnol. Tesaro's niraparib significantly improved progression-free survival for patients with ovarian cancer in both cohorts of the phase 3 NOVA trial. Press Release, 29 June , ET.
Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. Safety and activity of anti-PD-L1 antibody in patietns with advanced cancer. Safety and antitumor activity of anti-PD-1 antibody, niolumab, in patients with platinum-resistant ovarian cancer. Tewari KS. Advanced Cytoreductive Surgery Workshop report. Int J Gynecol Cancer. McDowell E. Three cases of extirpation of diseased ovaria. Eclectic Repertory Anal Rev. Houston R. An account of a dropsy in the left ovary of a woman, aged 58, cured by a large incision made in the side of the abdomen. Trans R Soc. Meigs JV. The surgical treatment of cancer of the ovary.
Clin Obstet Gynecol. Hudson CN.
A radical operation for fixed ovarian tumours. J Obstet Gynaecol Br Commonw. Barber HR, Brunschwig A. Pelvic exenteration for locally advanced and recurrent ovarian cancer.
Ovarian Cancer Patient Management and Screening | Gynecologic Cancer Curriculum | CDC
Review of 22 cases. Br Med J. Griffiths CT. Surgical resection of tumor bulk in the primary treatment of ovarian carcinoma.
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- Interval cytoreduction in advanced ovarian cancer: Santa Casa São Paulo experience.
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Natl Cancer Inst Monogr. Survival effect of maximal cytoreductive surgery for advanced ovarian carcinoma during the platinum era: A Meta-analysis. Sugarbaker PH. Complete parietal and visceral peritonectomy of the pelvis for advanced primary and recurrent ovarian cancer. Cancer Treat Res. History of radical and reconstructive surgery for gynecologic cancer.
Halstead WS. The results of operations for the cure of cancer of the breast performed at the Johns Hopkins Hospital from June to January Johns Hopkins Hosp Rep ; Clark JG.
A more radical method for performing hysterectomy for cancer of the uterus. Historical development of cytoreductive surgery for ovarian cancer. Zug: Informa Healthcare; Intraperitoneal cisplatin plus intravenous cyclophosphamide versus intravenous cisplatin plus intravenous cyclophosphamide for stage III ovarian cancer. Cyclophosphamide and cisplatin compared with paclitaxel and cisplatij in patients with stage III and stage IV ovarian cancer. Phase III trial of standard-dose intravenous cisplatin plus paclitaxel versus moderately high-dose carboplatin followed by intravenous paclitaxel and intraperitoneal cisplatin in small-volume stage III ovarian carcinoma.
Folkman J. Tumor angiogenesis: therapeutic implications. Francis Daniels Moore. In: Biographical Memoirs: Volume Brennan MF, Francis D. Moore, MD Ann Surg. Download references. The author KST declares that he has no competing interest.
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None; this workshop is not for profit. Correspondence to Krishnansu S. Reprints and Permissions. Search all BMC articles Search.
Surgery for Ovarian Cancer
Meeting report Open Access Published: 24 October Fifth annual workshop of cytoreductive surgery for advanced ovarian cancer and peritoneal surface malignancies Krishnansu S. Introduction: ovarian cancer — the clinical problem Cytoreductive surgery followed by adjuvant systemic platinum- and taxane-based combination chemotherapy continues to represent standard treatment of advanced ovarian cancer.
Global and U. Interest in surgical workshops for advanced ovarian cancer. Full size image.